Seksuell aktivitet kan være ekstra belastende for hjertet. Dersom du har hjerteproblemer eller tror du kan ha et hjerteproblem er det viktig at du opplyser om dette i samtalen med farmasøyten i apotek.
When sexual stimulation leads to area release of NO, inhibition of PDE5 by sildenafil will cause improved levels of cGMP from the corpus cavernosum, resulting in easy muscle relaxation and inflow of blood to your corpus cavernosum. Sildenafil at recommended doses has no outcome within the absence of sexual stimulation.
Quit sexual activity and have medical assist without delay if you receive signs and symptoms which include upper body discomfort, dizziness, or nausea during sexual intercourse.
Really serious coronary heart signs and symptoms which include rapid, irregular, or pounding heartbeats; fluttering in the upper body; shortness of breath; and unexpected dizziness, lightheartedness, or passing out;
Administration of VIAGRA with nitric oxide donors like organic nitrates or organic and natural nitrites in any variety is contraindicated.
Hemic and Lymphatic: vaso-occlusive disaster: In a little, prematurely terminated study of REVATIO (sildenafil) in clients with pulmonary arterial hypertension (PAH) secondary to sickle cell ailment, vaso-occlusive crises requiring hospitalization ended up a lot more usually claimed in clients who been given sildenafil than in Those people randomized to placebo. The clinical relevance of this locating to Guys taken care of with VIAGRA for ED just isn't known.
Sildenafil is also at times made use of to take care of pulmonary hypertension (significant blood pressure from the blood vessels that offer the lungs).
Sildenafil enhances the effect of NO by inhibiting phosphodiesterase style 5 (PDE5), which can be chargeable for degradation of cGMP in website the corpus cavernosum. Sildenafil has no immediate relaxant effect on isolated human corpus cavernosum.
[34] Studies on the results of sildenafil when made use of recreationally are minimal, but advise it has minimal result when utilized by people who would not have erectile dysfunction. In a single review, a 25 mg dose was proven to result in no considerable modify in erectile top quality, but did reduce the postejaculatory refractory time.[35] This review also famous a major placebo effect in the Regulate group.[35]
Physicians really should alert individuals that prolonged erections larger than four hours and priapism (unpleasant erections larger than six several hours in period) are already reported infrequently due to the fact market acceptance of VIAGRA.
Sildenafil was adverse in in vitro bacterial and Chinese hamster ovary cell assays to detect mutagenicity, As well as in vitro human lymphocytes As well as in vivo mouse micronucleus assays to detect clastogenicity.
VIAGRA has systemic vasodilatory Homes and will additional lower hypertension in sufferers taking antihypertensive medications.
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It truly is impossible to find out whether these events are similar directly to the use of PDE5 inhibitors, on the patient's underlying vascular threat aspects or anatomical defects, to a combination of these components, or to other variables [see WARNINGS AND PRECAUTIONS and Client INFORMATION].